+31 (0)317 466 260 info@amrif.eu


The therapeutic functions of alkaline phosphatase have a strong scientific base. Built on which we have developed intellectual property in several indications.


Chandrupatla DMSH, Molthoff CFM, Ritsema WIGR, Vos R, Elshof E, Matsuyama T, Low PS, Musters RJP, Hammond A, Windhorst AD, Lammertsma AA, van der Laken CJ, Brands R, Jansen G.
Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate.
Transl Res. 2018 Sep;199:24-38. doi: 10.1016/j.trsl.2018.04.001. Epub 2018 May 17. PMID: 29802817

Presbitero A, Mancini E, Brands R, Krzhizhanovskaya VV, Sloot PMA. Supplemented Alkaline Phosphatase Supports the Immune Response in Patients Undergoing Cardiac Surgery: Clinical and Computational Evidence. Front Immunol. 2018 Oct 11;9:2342. doi: 10.3389/fimmu.2018.02342. eCollection 2018.

Pike AF, Kramer NI, Blaauboer BJ, Seinen W, Brands R. An AP Transport Mechanism in the Pathogenesis of Alzheimer’s Disease and Neurodegeneration. Chem Biol Interact. 2014 Dec 11. pii: S0009-2797(14)00384-6. doi: 10.1016/j.cbi.2014.12.006. Review.

 Morris et al. Leaky brain in neurological and psychiatric disorders: Drivers and consequences.  Just N Z J Psychiatry.  2018 Oct;52(10):924-948. doi: 10.1177/0004867418796955. 

Fawley et al. Intestinal alkaline phosphatase: a summary of its role in clinical disease. J of Surgical Research 2016; (202) 225-234  

Fiechter et al. Bovine intestinal alkaline phosphatase reduces inflammation after induction of acute myocardial infarction in mice. Cardiology Research 2011; 2(5):236-242

Kaliannan et al. Intestinal alkaline phosphatse prevents metabolic syndrome in mice. PNAS 2013; vol. 110 no. 17 7003-7008

Kats et al. Endotoxin release in cardiac surgery with cardiopulmonary bypass: pathophysiology and possible therapeutic strategies. An update. Eur J Cardiothoracic Surg. 2011; Apr; 39(4):451-8

Kats et al. Prophylactic treatment with alkaline phosphatase in cardiac surgery induces endogenous alkaline phosphatase release. Int. J. Artificial Organs 2012; 35 (2): 144-151  

Lalles et al. Intestinal alkaline phosphatase: novel functions and protective effects. Nutrition Reviews 2014; Vol. 72(2):82-94

Moss et al. Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate. Am J Physiol Gastrointest Liver Physiol 2013; 304(6): G597-G604.

Malo et al. Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut 2010; 59(11): 1476-84

 Pike et al., A novel hypothesis for an alkaline phosphatase ‘rescue’ mechanism in the hepatic acute phase immune response. Biochim Biophys Acta. 2013 Dec;1832(12):2044-56



P 2252324 B1

Alkaline Phosphatase for Increasing the Activity of the Immune System of a Mammal at Risk of Inflammatory Diseases.

US 8784805 B2

Method for Increasing the Activity of the Immune System of a Mammal at Risk of Inflammatory Diseases.



AMRIF has filed an additional patent for use of alkaline phosphatase to treat arthritis.