A clinical phase 2 trial in RA patients is applied for to be carried out at VUmc Amsterdam (Amsterdam UMC) under supervision of Dr C van der laken. The study follows Proof of Principle studies in a novel arthritic rat animal model (published Chandrupatla et al 2018 Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate. Translational Research Volume 199, September 2018, Pages 24-38 doi.org/10.1016/j.trsl.2018.04.001 A phase 1 study with the same hRESCAP compounds was performed air an earlier stage (published Vlaming et al 2015 Microdosing of a carbon-14 labeled protein in healthy volunteers accurately predicts its pharmacokinetics at therapeutic dosages. Clin Pharmacol Ther. 2015 Aug;98(2):196-204. doi: 10.1002/cpt.131. Epub 2015 May 19.